442 research outputs found

    The critical role of volcano monitoring in risk reduction

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    International audienceData from volcano-monitoring studies constitute the only scientifically valid basis for short-term forecasts of a future eruption, or of possible changes during an ongoing eruption. Thus, in any effective hazards-mitigation program, a basic strategy in reducing volcano risk is the initiation or augmentation of volcano monitoring at historically active volcanoes and also at geologically young, but presently dormant, volcanoes with potential for reactivation. Beginning with the 1980s, substantial progress in volcano-monitoring techniques and networks ? ground-based as well space-based ? has been achieved. Although some geochemical monitoring techniques (e.g., remote measurement of volcanic gas emissions) are being increasingly applied and show considerable promise, seismic and geodetic methods to date remain the techniques of choice and are the most widely used. Availability of comprehensive volcano-monitoring data was a decisive factor in the successful scientific and governmental responses to the reawakening of Mount St. elens (Washington, USA) in 1980 and, more recently, to the powerful explosive eruptions at Mount Pinatubo (Luzon, Philippines) in 1991. However, even with the ever-improving state-of-the-art in volcano monitoring and predictive capability, the Mount St. Helens and Pinatubo case histories unfortunately still represent the exceptions, rather than the rule, in successfully forecasting the most likely outcome of volcano unrest

    Area deprivation across the life course and physical capability in mid-life: findings from the 1946 British Birth Cohort

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    Physical capability in later life is influenced by factors occurring across the life course, yet exposures to area conditions have only been examined cross-sectionally. Data from the National Survey of Health and Development, a longitudinal study of a 1946 British birth cohort, were used to estimate associations of area deprivation (defined as percentage of employed people working in partly skilled or unskilled occupations) at ages 4, 26, and 53 years (residential addresses linked to census data in 1950, 1972, and 1999) with 3 measures of physical capability at age 53 years: grip strength, standing balance, and chair-rise time. Cross-classified multilevel models with individuals nested within areas at the 3 ages showed that models assessing a single time point underestimate total area contributions to physical capability. For balance and chair-rise performance, associations with area deprivation in midlife were robust to adjustment for individual socioeconomic position and prior area deprivation (mean change for a 1-standard-deviation increase: balance, −7.4% (95% confidence interval (CI): −12.8, −2.8); chair rise, 2.1% (95% CI: −0.1, 4.3)). In addition, area deprivation in childhood was related to balance after adjustment for childhood socioeconomic position (−5.1%, 95% CI: −8.7, −1.6). Interventions aimed at reducing midlife disparities in physical capability should target the socioeconomic environment of individuals—for standing balance, as early as childhood

    Assessing the Impact of Lead and Floe Sampling on Arctic Sea Ice Thickness Estimates from Envisat and CryoSat‐2

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    Multidecadal observations of sea ice thickness, in addition to those available for extent, are key to understanding long‐term variations and trends in the amount of Arctic sea ice. The European Space Agency's Envisat (2002–2010) and CryoSat‐2 (2010–present) satellite radar altimeter missions provide a continuous 17‐year dataset with the potential to estimate sea ice thickness. However, the satellite footprints are not equal in area and so different distributions of floes and leads are sampled by each mission. Here, we compare lead and floe sampling from Envisat and CryoSat‐2 to investigate the impact of geometric sampling differences on Arctic sea ice thickness estimates. We find that Envisat preferentially samples wider, thicker sea ice floes, and that floes in less consolidated ice regions are effectively thickened by off‐nadir ranging to leads. Consequently, Envisat sea ice thicknesses that are an average of 80 cm higher than CryoSat‐2 over first‐year ice and 23 cm higher over multiyear ice. By considering the along‐track distances between lead and floe measurements, we are able to develop a sea ice thickness correction that is based on Envisat's inability to resolve discrete surfaces relative to CryoSat‐2. This is a novel, physically based approach to addressing the bias between the satellites and reduces the average thickness difference to negligible values over first‐year and multiyear ice. Finally, we evaluate our new bias‐corrected Envisat sea ice thickness product using independent airborne, moored‐buoy and submarine data. The European Space Agency's Envisat and CryoSat‐2 satellites have the potential to produce a continuous record of Arctic sea ice thickness since 2002, but this is complicated by the fact that the satellites do not sample the sea ice surface in the same way. We find that Envisat is only able to sample larger, thicker sea ice relative to CryoSat‐2, because of its poorer resolution. In this paper we account for these differences in sampling to combine Arctic sea ice thickness estimates from two the satellite missions. Applying a sea ice thickness bias correction to Envisat data reduces the ice thickness difference between Envisat and CryoSat‐2 from an average of 53.0 to 0.5 c

    Association of a Genetic Risk Score With Body Mass Index

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    Improving upon the efficiency of complete case analysis when covariates are MNAR.

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    Missing values in covariates of regression models are a pervasive problem in empirical research. Popular approaches for analyzing partially observed datasets include complete case analysis (CCA), multiple imputation (MI), and inverse probability weighting (IPW). In the case of missing covariate values, these methods (as typically implemented) are valid under different missingness assumptions. In particular, CCA is valid under missing not at random (MNAR) mechanisms in which missingness in a covariate depends on the value of that covariate, but is conditionally independent of outcome. In this paper, we argue that in some settings such an assumption is more plausible than the missing at random assumption underpinning most implementations of MI and IPW. When the former assumption holds, although CCA gives consistent estimates, it does not make use of all observed information. We therefore propose an augmented CCA approach which makes the same conditional independence assumption for missingness as CCA, but which improves efficiency through specification of an additional model for the probability of missingness, given the fully observed variables. The new method is evaluated using simulations and illustrated through application to data on reported alcohol consumption and blood pressure from the US National Health and Nutrition Examination Survey, in which data are likely MNAR independent of outcome

    Appropriate inclusion of interactions was needed to avoid bias in multiple imputation

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    OBJECTIVE: Missing data are a pervasive problem, often leading to bias in complete records analysis (CRA). Multiple imputation (MI) via chained equations is one solution, but its use in the presence of interactions is not straightforward. STUDY DESIGN AND SETTING: We simulated data with outcome Y dependent on binary explanatory variables X and Z and their interaction XZ. Six scenarios were simulated (Y continuous and binary, each with no interaction, a weak and a strong interaction), under five missing data mechanisms. We use directed acyclic graphs to identify when CRA and MI would each be unbiased. We evaluate the performance of CRA, MI without interactions, MI including all interactions, and stratified imputation. We also illustrated these methods using a simple example from the National Child Development Study (NCDS). RESULTS: MI excluding interactions is invalid and resulted in biased estimates and low coverage. When XZ was zero, MI excluding interactions gave unbiased estimates but overcoverage. MI including interactions and stratified MI gave equivalent, valid inference in all cases. In the NCDS example, MI excluding interactions incorrectly concluded there was no evidence for an important interaction. CONCLUSIONS: Epidemiologists carrying out MI should ensure that their imputation model(s) are compatible with their analysis model

    Joint modelling rationale for chained equations.

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    BACKGROUND: Chained equations imputation is widely used in medical research. It uses a set of conditional models, so is more flexible than joint modelling imputation for the imputation of different types of variables (e.g. binary, ordinal or unordered categorical). However, chained equations imputation does not correspond to drawing from a joint distribution when the conditional models are incompatible. Concurrently with our work, other authors have shown the equivalence of the two imputation methods in finite samples. METHODS: Taking a different approach, we prove, in finite samples, sufficient conditions for chained equations and joint modelling to yield imputations from the same predictive distribution. Further, we apply this proof in four specific cases and conduct a simulation study which explores the consequences when the conditional models are compatible but the conditions otherwise are not satisfied. RESULTS: We provide an additional "non-informative margins" condition which, together with compatibility, is sufficient. We show that the non-informative margins condition is not satisfied, despite compatible conditional models, in a situation as simple as two continuous variables and one binary variable. Our simulation study demonstrates that as a consequence of this violation order effects can occur; that is, systematic differences depending upon the ordering of the variables in the chained equations algorithm. However, the order effects appear to be small, especially when associations between variables are weak. CONCLUSIONS: Since chained equations is typically used in medical research for datasets with different types of variables, researchers must be aware that order effects are likely to be ubiquitous, but our results suggest they may be small enough to be negligible
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